Effect of APOE on the longitudinal DMN changes. The comparison of the DMN changes over time between APOE ε42 and APOE ε41 showed a significant increased rsFC in the frontal and prefrontal areas over time [245 voxels, [30 50 28], PFWE , .001]. No effects of global amyloid load or an interaction effect between the amyloid status and APOE were found. The statistical maps were thresholded using TFCE and P , .05 familywise error corrected.